Astagraf XL (Tacrolimus)
0.75mg Tablet (Extended-Release)
1mg Tablet (Extended-Release)
4mg Tablet (Extended-Release)
To comply with Canadian International Pharmacy Association regulations you are permitted to order a 3-month supply or the closest package size available based on your personal prescription. read more
(ta kroe' li mus)Tacrolimus injection should only be given under the supervision of a doctor who is experienced in treating people who have had an organ transplant and in prescribing medications that decrease the activity of the immune system. Tacrolimus injection decreases the activity of your immune system. This may increase the risk that you will get a serious infection. If you experience any of the following symptoms, call your doctor immediately: sore throat; cough; fever; extreme tiredness; flu-like symptoms; warm, red, or painful skin; or other signs of infection. When your immune system is not working normally, there may be a greater risk that you will develop cancer, especially lymphoma (a type of cancer that begins in the cells of the immune system). The longer you receive tacrolimus injection or other medications that decrease the activity of the immune system, and the higher your doses of these medications, the more this risk may increase. If you experience any of the following symptoms of lymphoma, call your doctor immediately: swollen lymph nodes in the neck, armpits, or groin; weight loss; fever; night sweats; excessive tiredness or weakness; cough; trouble breathing; chest pain; or pain, swelling, or fullness in the stomach area. Talk to your doctor about the risks of receiving tacrolimus injection.
Before receiving tacrolimus injection,
- tell your doctor and pharmacist if you are allergic to tacrolimus, any other medications, polyoxyl 60 hydrogenated castor oil (HCO-60) or other medications that contain castor oil. Ask your doctor or pharmacist if you do not know if a medication you are allergic to contains castor oil.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: amphotericin B (Abelcet, Ambisome, Amphotec); antacids; certain antibiotics including aminoglycosides such as amikacin, gentamicin, neomycin (Neo-Fradin), streptomycin, and tobramycin (Tobi), and macrolides such as clarithromycin (Biaxin), erythromycin (EES, E-Mycin, Erythrocin), and troleandomycin (TAO) (not available in the US); antifungal medications such as clotrimazole (Lotrimin, Mycelex), fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral) and voriconazole (Vfend); bromocriptine (Parlodel); calcium channel blockers such as diltiazem (Cardizem), nicardipine (Cardene), nifedipine (Adalat, Procardia), and verapamil (Calan, Covera, Isoptin); caspofungin (Cancidas); chloramphenicol; cimetidine (Tagamet); cisapride (Propulsid) (not available in the U.S.); cisplatin (Platinol); danazol (Danocrine); certain diuretics ('water pills'); ganciclovir (Cytovene); hormonal contraceptives (birth control pills, patches, rings, inserts, or injections); HIV protease inhibitors such as indinavir (Crixivan), nelfinavir (Viracept), and ritonavir (Norvir); lansoprazole (Prevacid); certain medications for seizures such as carbamazepine (Tegretol), phenobarbital, and phenytoin (Dilantin); methylprednisolone (Medrol); metoclopramide (Reglan); nefazodone; omeprazole (Prilosec); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane); and sirolimus (Rapamune). Your doctor may need to change the doses of your medications or monitor you more carefully for side effects. Many other medications may interact with tacrolimus, so tell your doctor about all the medications you are taking, even those that do not appear on this list.
- tell your doctor if you are receiving or have recently stopped receiving cyclosporine (Gengraf, Neoral, Sandimmune). If you were receiving cyclosporine, your doctor will probably not start to give you tacrolimus injection until 24 hours after you received your last dose of cyclosporine. If you stop receiving tacrolimus injection, your doctor will also tell you to wait 24 hours before starting to take cyclosporine.
- tell your doctor and pharmacist what herbal products you are taking, especially St. John's wort.
- tell your doctor if you have or have ever had heart, kidney, or liver disease.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while receiving tacrolimus injection, call your doctor.
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are receiving tacrolimus injection.
- you should know that receiving tacrolimus injection may increase the risk that you will develop skin cancer. Protect yourself from skin cancer by avoiding unnecessary or prolonged exposure to sunlight or ultraviolet light (tanning beds) and wearing protective clothing, sunglasses, and sunscreen with a high skin protection factor (SPF).
- you should know that tacrolimus injection may cause high blood pressure. Your doctor will monitor your blood pressure carefully, and may prescribe medication to treat high blood pressure if it develops.
- you should know that there is a risk that you will develop diabetes during your treatment with tacrolimus injection. African American and Hispanic patients who have had kidney transplants have an especially high risk of developing diabetes during their treatment with tacrolimus injection. Tell your doctor if you or anyone in your family has or has ever had diabetes. If you experience any of the following symptoms, call your doctor immediately: excessive thirst; excessive hunger; frequent urination; blurred vision or confusion.
- do not have any vaccinations without talking to your doctor.
- uncontrollable shaking of a part of the body
- stomach pain
- loss of appetite
- difficulty falling asleep or staying asleep
- back or joint pain
- burning, numbness, pain or tingling in the hands or feet
- difficulty breathing or swallowing
- decreased urination
- pain or burning on urination
- swelling of the arms, hands, feet, ankles or lower legs
- weight gain
- unusual bleeding or bruising
- coma (loss of consciousness for a period of time)