Atripla (Efavirenz / Emtricitabine / Tenofovir Disoproxil Fumarate )
(℞) Prescription required. Can not be split. Product of Canada. Shipped from Canada.
To comply with Canadian International Pharmacy Association regulations you are permitted to order a 3-month supply or the closest package size available based on your personal prescription. read more
Efavirenz / Emtricitabine / Tenofovir Disoproxil Fumarate Information
(ef'' a vir' enz) (em'' trye sye' ta been) (ten of' oh vir)Efavirenz, emtricitabine, and tenofovir should not be used to treat hepatitis B virus infection (HBV; an ongoing liver infection). Tell your doctor if you have or think you may have HBV. Your doctor may test you to see if you have HBV before you begin your treatment with efavirenz, emtricitabine, and tenofovir. If you have HBV and you take efavirenz, emtricitabine, and tenofovir, your condition may suddenly worsen when you stop taking this medication. Your doctor will examine you and order lab tests regularly for several months after you stop taking this medication to see if your HBV has worsened. Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests before and during your treatment to check your body's response to efavirenz, emtricitabine, and tenofovir. Talk to your doctor about the risks of taking efavirenz, emtricitabine, and tenofovir.
Before taking efavirenz, emtricitabine, and tenofovir,
- tell your doctor and pharmacist if you are allergic to efavirenz, emtricitabine, or tenofovir, any other medications, or any of the ingredients in efavirenz, emtricitabine, and tenofovir tablets. Ask your pharmacist for a list of the ingredients.
- tell your doctor if you are taking voriconazole (Vfend) or elbasvir and grazoprevir (Zepatier). Your doctor will probably tell you not to take efavirenz, emtricitabine, and tenofovir if you are taking one or more of these medications.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, you are taking or plan to take. Be sure to mention any of the following: acyclovir (Sitavig, Zovirax); adefovir (Hepsera); antidepressants; artemether and lumefantrine (Coartem); atazanavir (Reyataz); atorvastatin (Lipitor, in Caduet); atovaquone and proguanil (Malarone); boceprevir (Victrelis); bupropion (Wellbutrin, Zyban, others); carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril); clarithromycin (Biaxin, in Prevpac); cidofovir; cyclosporine (Gengraf, Neoral, Sandimmune); darunavir (Prezista) with ritonavir (Norvir); delavirdine (Rescriptor); didanosine (Videx); diltiazem (Cardizem, Cartia, Diltzac, Taztia, Tiazac); ethinyl estradiol and norgestimate (Estarylla, Ortho-Tri-Cyclen, Sprintec, others); etonogestrel (Nexplanon, in Nuvaring); etravirine (Intelence); felodipine; fosamprenavir (Lexiva); ganciclovir (Cytovene); gentamicin; glecaprevir and pibrentasvir (Mavyret); indinavir (Crixivan); itraconazole (Onmel, Sporanox); ketoconazole; lamivudine (Epivir, Epivir HBV, in Combivir, Epzicom, Triumeq, Trizivir); ledipasvir and sofosbuvir (Harvoni); lopinavir and ritonavir (Kaletra); maraviroc (Selzentry); medications for anxiety, mental illness, and seizures; methadone (Dolophine, Methadose); nevirapine (Viramune); nicardipine (Cardene); nifedipine (Adalat, Afeditab, Procardia); phenobarbital; phenytoin (Dilantin, Phenytek); nonsteroidal anti-inflammatory medications (NSAIDs) such as celecoxib (Celebrex), ibuprofen (Advil, Motrin), meloxicam (Mobic), and naproxen (Aleve, Naprelan, Naprosyn); other HIV medications containing efavirenz, emtricitabine, and tenofovir (Complera, Descovy, Genvoya, Odefsey, Stribild, Truvada, Sustiva, Emtriva, Viread); posaconazole (Noxafil); pravastatin (Pravachol); raltegravir (Isentress); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane, in Rifamate, Rifater); ritonavir (Norvir, in Kaletra, Technivie, Viekira Pak); saquinavir (Invirase); sedatives; sertraline (Zoloft); sleeping pills; simeprevir (Olysio); simvastatin (Zocor, in Vytorin); sirolimus (Rapamune); sofosbuvir and velpatasvir (Epclusa); sofosbuvir, velpatasvir, and voxilaprevir (Vosevi); tacrolimus (Astagraf, Envarsus, Prograf); tranquilizers; valacyclovir (Valtrex); valganciclovir (Valcyte); verapamil (Calan, Covera, Tarka, Verelan); and warfarin (Coumadin, Jantoven). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with efavirenz, emtricitabine, and tenofovir, or may increase the risk that you will develop liver damage during your treatment with efavirenz, emtricitabine, and tenofovir, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
- tell your doctor what herbal products you are taking, especially St. John's wort.
- tell your doctor if you currently or have a prolonged QT interval (rare heart problem that may cause irregular heartbeat, fainting, or sudden death), or low levels of potassium or magnesium in your blood, ever drunk large amounts of alcohol, used street drugs, or over-used prescription medications. Also tell your doctor if you have or have ever had any of the conditions mentioned in the IMPORTANT WARNING section, depression or other mental illness, bone problems including osteoporosis (a condition in which the bones become thin and weak and break easily) or bone fractures, seizures, or liver or kidney disease.
- tell your doctor if you are pregnant, or plan to become pregnant. You should not become pregnant during your treatment and for 12 weeks after your final dose. If you can become pregnant, you will have to have a negative pregnancy test before you begin taking this medication and use effective birth control during your treatment. Efavirenz, emtricitabine, and tenofovir may interfere with the action of hormonal contraceptives (birth control pills, patches, rings, implants, or injections), so you should not use these as your only method of birth control during your treatment. You must use a barrier method of birth control (device that blocks sperm from entering the uterus such as a condom or a diaphragm) along with any other method of birth control you have chosen. Ask your doctor to help you choose a method of birth control that will work for you. If you become pregnant while taking efavirenz, emtricitabine, and tenofovir, call your doctor immediately.
- you should not breastfeed if you are infected with HIV or are taking efavirenz, emtricitabine, and tenofovir.
- you should be aware that your body fat may increase or move to different areas of your body, such as your upper back, neck (''buffalo hump''), breasts, and around your stomach. You may notice a loss of body fat from your face, legs, and arms.
- you should know that while you are taking medications to treat HIV infection, your immune system may get stronger and begin to fight other infections that were already in your body or cause other conditions to occur. This may cause you to develop symptoms of those infections or conditions. If you have new or worsening symptoms during your treatment with efavirenz, emtricitabine, and tenofovir be sure to tell your doctor.
- you should know that efavirenz, emtricitabine, and tenofovir may make you drowsy, dizzy, or unable to concentrate. Do not drive a car or operate machinery until you know how this medication affects you.
- you should know that efavirenz, emtricitabine, and tenofovir may cause changes in your thoughts, behavior, or mental health. Call your doctor immediately if you develop any of the following symptoms while you are taking efavirenz: depression, thinking about killing yourself or planning or trying to do so, angry or aggressive behavior, hallucinations (seeing things or hearing voices that do not exist), strange thoughts, or loss of touch with reality. Be sure your family knows which symptoms may be serious so that they can call your doctor if you are unable to seek treatment on your own.
- ask your doctor about the safe use of alcoholic beverages while you are taking efavirenz, emtricitabine, and tenofovir. Alcohol can make the side effects from efavirenz, emtricitabine, and tenofovir worse.
- you should know that efavirenz may cause potentially serious nervous system problems, including encephalopathy (a serious and potentially fatal disorder of the brain) months or years after you first take efavirenz, emtricitabine, and tenofovir. Although nervous system problems may begin after you have taken efavirenz, emtricitabine, and tenofovir for some time, it is important for you and your doctor to realize that they may be caused by efavirenz. Call your doctor right away if you experience problems with balance and coordination, confusion, memory problems, and other difficulties caused by abnormal brain function, at any time during your treatment with efavirenz, emtricitabine, and tenofovir. Your doctor may tell you to stop taking efavirenz, emtricitabine, and tenofovir.
- darkening of skin color, especially on the palms of the hands or the soles of the feet
- pale skin
- difficulty falling asleep or staying asleep
- feeling agitated, worried, or nervous
- abnormally happy mood
- unusual dreams
- joint or back pain
- decreased urination
- urinating large amounts
- increased thirst
- ongoing or worsening bone pain
- bone fractures
- pain in the in the arms, hands, feet, or legs
- muscle pain or weakness
- peeling, blistering, or shedding skin
- numbness, burning, or tingling in the hands, arms, feet, or legs
- swelling of the face, throat, tongue, lips, eyes, legs, ankles, or feet
- difficulty swallowing or breathing
- flu-like symptoms
- extreme tiredness
- yellowing of skin or eyes; light-colored bowel movements; dark yellow or brown urine; loss of appetite; pain in upper right part of stomach; or unusual bleeding or bruising
- weakness; muscle pain; shortness of breath or fast breathing; stomach pain with nausea and vomiting; cold or blue hands and feet; feeling dizzy or lightheaded; or fast or irregular heartbeat