Combivir (Zidovudine / Lamivudine)

They need to know if you have any of these conditions: -blood or bone marrow problems -drink alcohol-containing drinks -kidney disease -liver disease -an unusual or allergic reaction to lamivudine, zidovudine, other medications, foods, dyes, or preservatives -pregnant or trying to become pregnant -breast-feeding

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Ask your doctor or pharmacist if this medicine should be taken with or without food. Sometimes you must take this medicine on an empty stomach, at least 30 minutes before or 2 hours after food. Take your medicine at regular intervals. Do not take your medicine more often than directed. For your anti-HIV therapy to work as well as possible, take each dose exactly as prescribed. Do not skip doses or stop your medicine even if you feel better. Skipping doses may make the HIV virus resistant to this medicine and other medicines. Do not stop taking except on your doctor's advice. Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

-atovaquone -doxorubicin -fluconazole -ganciclovir -interferon -methadone -nelfinavir -probenecid -ribavirin -ritonavir -sorbitol-containing medicines -stavudine -sulfamethoxazole; trimethoprim, SMX-TMP -trimethoprim -valproic acid

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

Visit your doctor or health care professional for regular check ups. Discuss any new symptoms with your doctor. You will need to have important blood work done while on this medicine. HIV is spread to others through sexual or blood contact. Talk to your doctor about how to stop the spread of HIV. If you have hepatitis B, talk to your doctor if you plan to stop or change your therapy. The symptoms of hepatitis B may get worse after you stop this medicine. Do not treat severe stomach pain, nausea or vomiting with over-the-counter medicines. Contact your doctor. This medicine can cause blood problems. You may have slow healing and a higher risk of infection while on this medicine. Try to avoid cutting or injuring yourself. Be careful not to damage to your teeth and gums when you brush or floss your teeth. This medicine may cause a decrease in vitamin B12. You should make sure that you get enough vitamin B12 while you are taking this medicine. Discuss the foods you eat and the vitamins you take with your health care professional.

Side effects that you should report to your doctor or health care professional as soon as possible: -allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue -breathing problems -dizziness -fast, irregular heartbeat -muscle pain or weakness -nausea, vomiting, unusual upset stomach or stomach pain -seizures -signs and symptoms of liver injury like dark yellow or brown urine; general ill feeling or flu-like symptoms; light-colored stools; loss of appetite; right upper belly pain; unusually weak or tired; yellowing of the eyes or skin -signs of infection like fever or chills; cough; sore throat -unusual bleeding or bruising Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome): -cough -diarrhea -trouble sleeping -headache -runny, stuffy nose

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Keep out of the reach of children. Store between 2 and 30 degrees C (36 and 86 degrees F). Keep the container tightly closed. Throw away any unused medicine after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.