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(soe" ni deg' ib)For all patients: Sonidegib should not be taken by women who are pregnant or who may become pregnant. There is a high risk that sonidegib will cause loss of the pregnancy or will cause the baby to be born with birth defects (physical problems that are present at birth). Do not donate blood or blood products while you are taking sonidegib and for at least 20 months after your treatment. Talk to your doctor about the risks of taking sonidegib. For female patients: If you can become pregnant, you will need to avoid becoming pregnant during your treatment with sonidegib. You must have a negative pregnancy test before the start of your treatment. You must use acceptable forms of birth control during your treatment and for at least 20 months after your treatment is completed. Your doctor will tell you which forms of birth control are acceptable. If you think you are pregnant, miss a menstrual period, or have sex without using birth control while taking sonidegib or within 20 months after your treatment, call your doctor immediately. For male patients: You must use a condom, even if you have had a vasectomy (surgery to prevent sperm from leaving your body and causing pregnancy), every time you have sexual contact with a female who is pregnant or able to become pregnant while you are taking sonidegib, and for at least 8 months after your treatment. Tell your doctor immediately if you have had unprotected sex with a woman who can become pregnant or if you think for any reason that your partner is pregnant. Do not donate semen while you are taking sonidegib or within 8 months after your treatment.
Before taking sonidegib,
- tell your doctor and pharmacist if you are allergic to sonidegib, any other medications, or any of the ingredients in sonidegib capsules. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: atazanavir (Reyataz); certain antifungals such as fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole, posaconazole (Noxafil), and voriconazole (Vfend); diltiazem (Cardizem, Cartia, Tiazac, others); efavirenz (Sustiva, in Atripla); modafinil (Provigil); nefazodone; rifabutin (Mycobutin); rifampin (Rifadin, Rifamate, Rifater, Rimactane); saquinavir (Invirase); certain medications for seizures such as carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril), phenobarbital, and phenytoin (Dilantin, Phenytek); and telithromycin (Ketek). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with sonidegib, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
- tell your doctor what herbal products you are taking, especially St. John's wort. Your doctor will probably tell you not to take St. John's wort while taking sonidegib.
- tell your doctor if you have or have ever had muscle disease.
- tell your doctor if you are breastfeeding. Your doctor may tell you not to breastfeed while you are taking sonidegib and for 20 months after your treatment.
- abdominal pain
- loss of appetite
- weight loss
- change in ability to taste food
- hair loss
- extreme tiredness
- missed menstrual periods
- muscle spasms
- unexplained muscle pain, tenderness or weakness
- dark or cola colored urine
- decreased urination
- inability to urinate