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(os pem' i feen)Taking ospemifene may increase the risk that you will develop endometrial cancer (cancer of the uterus [womb]). Tell your doctor if you have or have ever had cancer or if you have abnormal vaginal bleeding. Your doctor will probably tell you not to take ospemifene. If you have any unusual vaginal bleeding while you are taking ospemifene call your doctor immediately. Taking ospemifene also may increase the risk of stroke and blood clots. Tell your doctor if you smoke or if you have ever had a stroke; if you or anyone in your family has or has ever had blood clots; or if you have or have ever had high blood pressure, high blood levels of cholesterol or fats, diabetes, heart disease, or lupus (a condition in which the body attacks its own tissues causing damage and swelling). Your doctor will probably tell you not to take ospemifene. Talk to your doctor every 3 to 6 months to discuss if you should continue taking this medication. If you experience any of the following symptoms, stop taking ospemifene and call your doctor immediately: swelling or pain in your legs; warm or red skin; slow or difficult speech; dizziness or faintness; weakness or numbness of an arm or leg; sudden, severe headache; sudden changes in vision; pain in your chest, arms, back, neck or jaw; or shortness of breath. Keep all appointments with your doctor and the laboratory. Your doctor may order certain tests to check your body's response to ospemifene. Talk to your doctor about the risks and benefits of taking this medication.
Before taking ospemifene,
- tell your doctor and pharmacist if you are allergic to ospemifene, any other medications, or any of the ingredients in ospemifene tablets. Ask your pharmacist for a list of the ingredients.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antifungals such as itraconazole (Sporanox), fluconazole (Diflucan), ketoconazole (Nizoral); clarithromycin (Biaxin); estrogens such as (Premarin); estrogen agonists/antagonists such as tamoxifen (Nolvadex); medications for human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) such as indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), saquinavir (Fortovase, Invirase); nefazodone; or rifampin (Rifadin, Rimactane, in Rifamate). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor if you have or have ever had liver disease.
- tell your doctor if you are pregnant, plan to become pregnant, or are feeding. Ospemifene may cause fetal harm. If you become pregnant while taking ospemifene, call your doctor immediately.
- if you are having surgery, including dental surgery, or will be on bed rest, tell the doctor or dentist you are taking ospemifene.
- hot flashes or flushes
- vaginal discharge
- muscle spasms
- increased sweating
- swelling of the face, throat, tongue, lips. eyes, hands, feet, ankles, or lower legs
- difficulty swallowing or breathing