Before taking darunavir,
tell your doctor and pharmacist if you are allergic to darunavir, ritonavir, sulfa medications, any other medications, or any of the ingredients in darunavir tablets or suspension. Ask your pharmacist for a list of the ingredients or if you are unsure if a medication you are allergic to is a sulfa medication.
tell your doctor if you are taking any of the following medications: alfuzosin (Uroxatral); cisapride (Propulsid) (not available in the U.S.); dronedarone (Multaq); ergot-type medications such as dihydroergotamine (D.H.E. 45, Migranal), ergotamine (Ergomar, in Cafergot, in Migergot), and methylergonovine (Methergine); lovastatin (Mevacor, in Advicor); lurasidone (Latuda), midazolam (given by mouth); pimozide (Orap); ranolazine (Ranexa); rifampin (Rifadin, Rimactane, in Rifamate, in Rifater); sildenafil (only Revatio brand used for lung disease); simvastatin (Zocor, in Vytorin); St. John's wort; or triazolam (Halcion). Your doctor will probably tell you not to take darunavir. Also, if you have kidney or liver disease and are taking colchicine (Colcrys, Mitigare, in Col-Probenecid), your doctor will probably tell you not to take darunavir.
tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: anticoagulants ('blood thinners') such as apixaban (Eliquis), dabigatran etexilate (Pradaxa), rivaroxaban (Xarelto), and warfarin (Coumadin, Jantoven); antifungals such as itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), and voriconazole (Vfend); artemether/lumefantrine (Coartem); beta blockers such as carvedilol (Coreg), metoprolol (Lopressor, Toprol XL, in Dutoprol, in Lopressor HCT) and timolol (Betimol, Istalol, in Combigan, in Cosopt, others); boceprevir (no longer available in the U.S.; Victrelis); bosentan (Tracleer); budesonide (Entocort, Pulmicort, Uceris, others); buprenorphine (Belbuca, Buprenex, Butrans, in Suboxone, others); buspirone; calcium-channel blockers such as amlodipine (Norvasc, in Caduet), diltiazem (Cardizem CD, Cartia, XT, Diltzac, others), felodipine (Plendil), nicardipine (Cardene), nifedipine (Adalat CC, Afebitab CR, Procardia), and verapamil (Calan, Covera, Verelan, in Tarka); certain chemotherapy medications such as dasatinib (Sprycel), nilotinib (Tasigna), vinblastine, and vincristine (Marqibo Kit); cholesterol-lowering medications (statins) such as atorvastatin (Lipitor, in Caduet), pravastatin (Pravachol), and rosuvastatin (Crestor); clarithromycin (Biaxin, in Prevpac); certain medications for depression such as amitriptyline, desipramine (Norpramin), imipramine, nortriptyline, paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); dexamethasone; diazepam (Diastat, Valium); estazolam; fluticasone (Flonase, Flovent, in Advair); other medications for HIV including indinavir (Crixivan), lopinavir/ritonavir (Kaletra), maraviroc (Selzentry), and saquinavir (Invirase); hormonal (estrogen) contraceptives (birth control pills, patches, rings, implants, or injections); medications for irregular heartbeat including amiodarone (Cordarone, Nexterone, Pacerone), bepridil (no longer available in U.S.), digoxin (Lanoxin), disopyramide (Norpace), flecainide, lidocaine (Xylocaine), mexiletine, propafenone (Rythmol), and quinidine (in Nuedexta); certain medications for seizures such as carbamazepine (Carbatrol, Equetro, Tegretol, others), phenobarbital, and phenytoin (Dilantin, Phenytek); certain medications that suppress the immune system such as cyclosporine (Gengraf, Neoral, Sandimmune), everolimus (Afinitor, Zortress), sirolimus (Rapamune), and tacrolimus (Astagraf XL, Prograf); methadone (Dolophine, Methadose); certain phosphodiesterase inhibitors (PDE-5 inhibitors) used for erectile dysfunction such as avanafil (Stendra), sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra, Staxyn); prednisolone; quetiapine (Seroquel); rifabutin (Mycobutin); risperidone (Risperdal); salmeterol (Serevent, in Advair); simeprevir (Olysio), telaprevir (Incivek; no longer available in the U.S.); tadalafil (Adcirca); thioridazine; zolpidem (Ambien, Edluar, Intermezzo); and trazodone. Many other medications may also interact with darunavir, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
if you are taking didanosine (Videx), take it 1 hour before or 2 hours after you take darunavir.
tell your doctor if you have or have ever had diabetes or high blood sugar; hemophilia (bleeding disorder in which the blood does not clot properly); hepatitis (swelling of the liver caused by a virus), cirrhosis (a disease which causes scarring of liver tissue), or any other liver disease; or an infection that does not go away or that comes and goes such as cytomegalovirus (CMV; a viral infection that may cause symptoms in patients with weak immune systems), mycobacterium avium complex disease (MAC; a bacterial infection that may cause serious symptoms in people with AIDS), pneumonia, or tuberculosis (TB; a type of lung infection).
tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking darunavir, call your doctor. Do not breast-feed if you are infected with HIV or are taking darunavir.
you should know that darunavir may decrease the effectiveness of hormonal contraceptives (birth control pills, patches, rings, injections, or implants). Talk to your doctor about other ways to prevent pregnancy while you are taking this medication.
you should know that your body fat may increase or move to different areas of your body such as your breasts, upper back, neck, chest, and stomach area. Loss of fat from the legs, arms, and face can also happen.
you should know that you may experience hyperglycemia (increases in your blood sugar) while you are taking this medication, even if you do not already have diabetes. Tell your doctor immediately if you have any of the following symptoms while you are taking darunavir: extreme thirst, frequent urination, extreme hunger, blurred vision, or weakness. It is very important to call your doctor as soon as you have any of these symptoms, because high blood sugar that is not treated can cause a serious condition called ketoacidosis. Ketoacidosis may become life-threatening if it is not treated at an early stage. Symptoms of ketoacidosis include: dry mouth, nausea and vomiting, shortness of breath, breath that smells fruity, and decreased consciousness.
you should know that while you are taking medications to treat HIV infection, your immune system may get stronger and begin to fight other infections that were already in your body. This may cause you to develop symptoms of those infections. If you have new or worsening symptoms at anytime during your treatment with darunavir, be sure to tell your doctor.