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(gra nis' e tron)
- Take the foil pouch out of the carton. Tear open the foil pouch at the slit and remove the patch. Each patch is stuck onto a thin plastic liner and a separate rigid plastic film. Do not open the pouch in advance, because you must apply the patch as soon as you remove it from the pouch. Do not try to cut the patch into pieces.
- Peel the thin plastic liner off of the printed side of the patch. Throw the liner away.
- Bend the patch in the middle so that you can remove one piece of the plastic film from the sticky side of the patch. Be careful not to stick the patch to itself or to touch the sticky part of the patch with your fingers.
- Hold the part of the patch that is still covered with the plastic film, and apply the sticky side to your skin.
- Bend the patch back and remove the second piece of plastic film. Press the entire patch firmly in place and smooth it down with your fingers. Be sure to press firmly, especially around the edges.
- Wash your hands right away.
- When it is time to remove the patch, peel it off gently. Fold it in half so that it sticks to itself and dispose of it safely, so that it is out of the reach of children and pets. The patch cannot be reused.
- If there is any sticky residue on your skin, wash it away gently with soap and water. Do not use alcohol or dissolving liquids such as nail polish remover.
- Wash your hands after you handle the patch.
Before using transdermal granisetron,
- tell your doctor and pharmacist if you are allergic to granisetron, any other medications, any other skin patches, medical adhesive tape or dressings, or any of the ingredients in granisetron patches. Ask your pharmacist for a list of the ingredients.
- you should know that granisetron is also available as tablets and a solution (liquid) to be taken orally and as an injection. Do not take granisetron tablets or solution or receive granisetron injection while you are wearing a granisetron patch because you may receive too much granisetron.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: fentanyl (Abstral, Actiq, Duragesic, Fentora, Lazanda, Onsolis, Subsys); ketoconazole (Nizoral); lithium (Lithobid); medications to treat migraines such as almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex), and zolmitriptan (Zomig); methylene blue; mirtazapine (Remeron); monoamine oxidase (MAO) inhibitors including isocarboxazid (Marplan), linezolid (Zyvox), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate); phenobarbital; selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); and tramadol (Conzip, Ultram, in Ultracet). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor if you have paralytic ileus (condition in which digested food does not move through the intestines), stomach pain or swelling, or if you develop these symptoms during your treatment with transdermal granisetron.
- tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while using transdermal granisetron, call your doctor.
- plan to protect the granisetron patch and the skin around it from real and artificial sunlight (tanning beds, sunlamps). Keep the patch covered with clothing if you need to be exposed to sunlight during your treatment. You should also protect the area on your skin where the patch was applied from sunlight for 10 days after you remove the patch.
- skin redness lasting longer than 3 days after you remove the patch
- rash, redness, bumps, blisters, or itching of the skin under or around the patch
- tightness of the throat
- difficulty breathing or swallowing
- dizziness, light-headedness, or fainting
- fast, slow or irregular heartbeat
- hallucinations (seeing things or hearing voices that do not exist)
- excessive sweating
- nausea, vomiting, or diarrhea
- loss of coordination
- stiff or twitching muscles
- coma (loss of consciousness)