Viekira XR (Ritonavir / Ombitasvir / Paritaprevir / Dasabuvir)
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Ritonavir / Ombitasvir / Paritaprevir / Dasabuvir Information
(da sa' bue vir) (om bit' as vir) (par'' I ta' pre vir) (ri toe' na vir)You may already be infected with hepatitis B (a virus that infects the liver and may cause severe liver damage) but not have any symptoms of the disease. In this case, taking the combination of dasabuvir, ombitasvir, paritaprevir, and ritonavir may increase the risk that your infection will become more serious or life-threatening and you will develop symptoms. Tell your doctor if you have or ever had a hepatitis B virus infection. Your doctor will order a blood test to see if you have or ever had a hepatitis B infection. Your doctor will also monitor you for signs of hepatitis B infection during and for several months after your treatment. If necessary, your doctor may give you medication to treat this infection before and during your treatment with the combination of dasabuvir, ombitasvir, paritaprevir, and ritonavir. If you experience any of the following symptoms during or after your treatment, call your doctor immediately: excessive tiredness, yellowing of the skin or eyes, loss of appetite, nausea or vomiting, pale stools, stomach pain, or dark urine. Keep all appointments with your doctor and the laboratory. Your doctor may order certain tests before, during, and after your treatment to check your body's response to the combination of dasabuvir, ombitasvir, paritaprevir, and ritonavir. Talk to your doctor about the risk(s) of taking the combination of dasabuvir, ombitasvir, paritaprevir, and ritonavir.
Before taking dasabuvir, ombitasvir, paritaprevir, and ritonavir,
- tell your doctor and pharmacist if you are allergic to dasabuvir, ombitasvir, paritaprevir, and ritonavir, any other medications, or any of the ingredients in dasabuvir, ombitasvir, paritaprevir, and ritonavir extended-release tablets. If you have had a serious or life-threatening reaction to ritonavir (rash, blistering or peeling of the skin), your doctor will probably tell not to take dasabuvir, ombitasvir, paritaprevir, and ritonavir.Ask your pharmacist or check the Medication Guide for a list of the ingredients.
- tell your doctor if you are taking alfuzosin (Uroxatral); atorvastatin (Lipitor, in Caduet); carbamazepine (Carbatrol, Epitol, Equetro, Tegretol); cisapride (Propulsid; no longer available in U.S.); dronedarone (Multaq); efavirenz (Sustiva, in Atripla); ergot-containing medicines such as dihydroergotamine mesylate (D.H.E. 45, Migranal), ergotamine (Ergomar, in Cafergot, in Migergot), and methylergonovine (Methergine); ethinyl estradiol oral contraceptives such as certain ('birth control pills'), patches, hormonal vaginal rings, and other ethinyl estradiol products; everolimus (Afinitor, Zortress); gemfibrozil (Lopid); lovastatin (Altoprev); lurasidone (Latuda); midazolam (by mouth); phenytoin (Dilantin, Phenytek); phenobarbital; pimozide (Orap); ranolazine (Ranexa); rifampin (Rifadin, Rimactane, in Rifamate, in Rifater); sildenafil (Revatio) for treatment of pulmonary arterial hypertension; simvastatin (Flolipid, Zocor, in Vytorin); sirolimus (Rapamune); St. John's wort; tacrolimus (Astagraf XL, Envarsus XR, Prograf); or triazolam (Halcion). Also, tell your doctor if you are taking colchicine (Colcrys, Mitigare) and have liver or kidney disease. Your doctor will probably tell you not to take dasabuvir, ombitasvir, paritaprevir, and ritonavir if you are taking one or more of these medications.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: acetaminophen and hydrocodone (Anexsia, Zyfrel); alprazolam (Xanax); angiotensin receptor blockers (ARBs) such as candesartan (Atacand, in Atacand HCT), losartan (Cozaar, in Hyzaar), or valsartan (Diovan, in Diovan HCT, in Exforge); buprenorphine and naloxone (Suboxone, Zubsolv); calcium channel blockers such as amlodipine (Norvasc), diltiazem (Cardizem, Dilacor, Tiazac, others), nifedipine (Adalat, Procardia), or verapamil (Calan, Verelan, others); carisoprodol (Soma); cyclobenzaprine (Amrix); cyclosporine (Gengraf, Neoral, Sandimmune); diazepam (Valium); fluticasone (Flonase, Flovent, in Advair); furosemide (Lasix); ketoconazole; medications for irregular heartbeat such as amiodarone (Nexterone, Pacerone), bepridil (no longer available in the U.S.), disopyramide (Norpace), flecainide, lidocaine (Xylocaine), mexiletine, propafenone (Rythmol), or quinidine (in Nuedexta); metformin (Glucophage, Riomet, others); omeprazole (Prilosec); pravastatin (Pravachol); quetiapine (Seroquel); rilpivirine (Edurant; in Complera, in Odefsey); ritonavir (Norvir, in Kaletra) used in combination with other HIV protease inhibitors such as atazanavir (Reyataz), darunavir (Prezista), and lopinavir (in Kaletra); rosuvastatin (Crestor); salmeterol (Serevent, in Advair); and voriconazole (Vfend). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor if you have any type of liver disease other than hepatitis C. Your doctor may tell you not to take dasabuvir, ombitasvir, paritaprevir, and ritonavir.
- tell your doctor if you have ever had a liver transplant or human immunodeficiency virus (HIV).
- tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking dasabuvir, ombitasvir, paritaprevir, and ritonavir, call your doctor.
- you should know that dasabuvir, ombitasvir, paritaprevir, and ritonavir may decrease the effectiveness of hormonal contraceptives (birth control pills, patches, rings, implants, injections, and intrauterine devices). Use another form of birth control while you are taking dasabuvir, ombitasvir, paritaprevir, and ritonavir and for 2 weeks after your final dose. Talk to your doctor about types of birth control that will work for you during and after your treatment with dasabuvir, ombitasvir, paritaprevir, and ritonavir.
- remember not to drink alcohol within 4 hours of taking dasabuvir, ombitasvir, paritaprevir, and ritonavir extended-release tablets.
- difficulty falling asleep or staying asleep
- muscle spasms
- reddening of the skin
- fatigue or lack of energy