Before using umeclidinium and vilanterol,
tell your doctor and pharmacist if you are allergic to umeclidinium, vilanterol, any other medications, milk protein, or any of the ingredients in umeclidinium and vilanterol inhalation. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
tell your doctor if you use another LABA such as such as arformoterol (Brovana), formoterol (Perforomist, in Bevespi Aerosphere, Duaklir Pressair, Dulera, Symbicort), indacaterol (Arcapta), olodaterol (Striverdi Respimat, in Stiolto Respimat), or salmeterol (Serevent, in Advair). Your doctor will tell you which medication you should use and which medication you should stop using.
tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antifungals such as itraconazole (Onmel, Sporanox, Tolsura), ketoconazole, and voriconazole (Vfend); antihistamines; atropine; beta-blockers such as atenolol (Tenormin), labetalol (Trandate), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), and propranolol (Inderal, Innopran); clarithromycin; conivaptan (Vaprisol); diuretics ('water pills'); HIV protease inhibitors such as indinavir (Crixivan), lopinavir (in Kaletra), nelfinavir (Viracept), ritonavir (Norvir), and saquinavir (Invirase); other medications for COPD including aclidinium (Tudorza Pressair), ipratropium (Atrovent HFA), and tiotropium (Spiriva); medications for irritable bowel disease, motion sickness, Parkinson's disease, ulcers, or urinary problems; and nefazodone. Also tell your doctor and pharmacist if you are taking the following medications or have stopped taking them during the past 2 weeks: antidepressants such as amitriptyline, amoxapine, clomipramine (Anafranil), desipramine (Norpramin), doxepin (Silenor, Zonalon), imipramine (Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil); amiodarone (Nexterone, Pacerone); anagrelide (Agrylin); chloroquine; chlorpromazine; cilostazol; ciprofloxacin (Cipro); citalopram (Celexa); clarithromycin; disopyramide (Norpace); dofetilide (Tikosyn); donepezil (Aricept); dronedarone (Multaq); escitalopram (Lexapro); flecainide (Tambocor); fluconazole (Diflucan); haloperidol (Haldol); ibutilide (Corvert); levofloxacin; methadone (Dolophine, Methadose); moxifloxacin (Avelox); ondansetron (Zuplenz, Zofran); pentamidine (Pentam); pimozide (Orap); procainamide; quinidine (in Nuedexta); sotalol (Betapace, Sorine, Sotylize); thioridazine; and monoamine oxidase (MAO) inhibitors such as isocarboxazid (Marplan), linezolid (Zyvox), phenelzine (Nardil), rasagiline (Azilect), selegiline (Emsam, Zelapar), and tranylcypromine (Parnate). Many other medications may also interact with umeclidinium and vilanterol, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
tell your doctor if you have asthma. Your doctor will tell you not to use umeclidinium and vilanterol unless you are using it along with an inhaled steroid medication.
tell your doctor if you have or have ever had high blood pressure, irregular heartbeat, QT prolongation (an irregular heart rhythm that can lead to fainting, loss of consciousness, seizures, or sudden death), seizures, diabetes, glaucoma (an eye disease), urinary retention (difficulty urinating), prostate or bladder problems, or heart, thyroid, or liver disease.
tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while using umeclidinium and vilanterol, call your doctor.
you should know that umeclidinium and vilanterol inhalation sometimes causes wheezing and difficulty breathing immediately after it is inhaled. If this happens, call your doctor right away. Do not use umeclidinium and vilanterol inhalation again unless your doctor tells you that you should.