Before taking iloperidone,
tell your doctor and pharmacist if you have had a serious allergic reaction (difficulty breathing or swallowing or swelling of the face, lips, throat, tongue, hands, or feet) to iloperidone. Your doctor will probably tell you not to take iloperidone. Also tell your doctor if you are allergic to any other medications, or any of the ingredients in iloperidone tablets. Ask your pharmacist for a list of the ingredients.
tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: amiodarone (Cordarone, Pacerone); antidepressants; antifungal medications such as itraconazole (Sporanox) and ketoconazole (Nizoral); bupropion (Aplenzin, Wellbutrin, Zyban); chlorpromazine; clarithromycin (Biaxin); fluoxetine (Prozac, Sarafem); gatifloxacin (Tequin) (not available in the U.S.); certain HIV protease inhibitors such as indinavir (Crixivan), nelfinavir (Viracept), and ritonavir (Norvir, in Kaletra); levo-alpha-acetylmethadol (ORLAAM) (not available in the U.S.); methadone (Dolophine, Methadose); medications for mental illness, high blood pressure, or seizures; moxifloxacin (Avelox); nefazodone; paroxetine (Paxil, Pexeva); pentamidine (Nebupent, Pentam); procainamide; quinidine; sedatives; sleeping pills; sotalol (Betapace); thioridazine or tranquilizers. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
tell your doctor if you use or have ever used street drugs or have overused prescription medications, or have or have had thoughts about harming or killing yourself. Also tell your doctor if you or anyone in your family has or has ever had diabetes and if you have or have ever had prolonged QT interval (a rare heart problem that may cause irregular heartbeat, fainting, or sudden death), a slow or irregular heartbeat, a recent heart attack, heart failure, dyslipidemia (high cholesterol levels), a low level of potassium or magnesium in your blood, seizures, breast cancer, trouble keeping your balance, any condition that makes it difficult for you to swallow, or heart or liver disease. Also tell your doctor if you have a low level of white blood cells or if you have ever developed a low level of blood cells as a side effect of a medication that you took. Also tell your doctor if you have severe vomiting or diarrhea or become dehydrated at any time during your treatment.
tell your doctor if you are pregnant, especially if you are in the last few months of your pregnancy, or if you plan to become pregnant or are breastfeeding. If you become pregnant while taking iloperidone, call your doctor. Iloperidone may cause problems in newborns following delivery if it is taken during the last months of pregnancy.
you should know that iloperidone may affect your thinking, judgment, and ability to move. Do not drive a car or operate machinery until you know how this medication affects you.
ask your doctor about the safe use of alcoholic beverages while you are taking iloperidone. Alcohol can make the side effects from iloperidone worse.
you should know that you may experience hyperglycemia (increases in your blood sugar) while you are taking this medication, even if you do not already have diabetes. If you have schizophrenia, you are more likely to develop diabetes than people who do not have schizophrenia, and taking iloperidone or similar medications may increase this risk. Tell your doctor immediately if you have any of the following symptoms while you are taking iloperidone: extreme thirst, frequent urination, extreme hunger, blurred vision, or weakness. It is very important to call your doctor as soon as you have any of these symptoms, because high blood sugar that is not treated can cause a serious condition called ketoacidosis. Ketoacidosis may become life-threatening if it is not treated at an early stage. Symptoms of ketoacidosis include: dry mouth, nausea and vomiting, shortness of breath, breath that smells fruity, and decreased consciousness.
you should know that iloperidone may cause dizziness, lightheadedness, fast heartbeat, and fainting when you get up too quickly from a lying position. This is more common when you first start taking iloperidone or when your dose is increased. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.
you should know that taking iloperidone may make it harder for your body to cool down if it gets very hot. Tell your doctor if you plan to do vigorous exercise or be exposed to extreme heat.