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Medroxyprogesterone Injection



(me drox' ee proe jes' te rone)

Depo-Provera®
depo-subQ provera 104®
Lunelle® (as a combination product containing Estradiol, Medroxyprogesterone)¶

acetoxymethylprogesterone
methylacetoxyprogesterone

Medroxyprogesterone injection may decrease the amount of calcium stored in your bones. The longer you use this medication, the more the amount of calcium in your bones may decrease. The amount of calcium in your bones may not return to normal even after you stop using medroxyprogesterone injection.
Loss of calcium from your bones may cause osteoporosis (a condition in which the bones become thin and weak) and may increase the risk that your bones might break at some time in your life, especially after menopause (change of life).
The amount of calcium in the bones usually increases during the teenage years. A decrease in bone calcium during this important time of bone strengthening may be especially serious. It is not known whether your risk of developing osteoporosis later in life is greater if you start to use medroxyprogesterone injection when you are a teenager or young adult. Tell your doctor if you or anyone in your family has osteoporosis; if you have or have ever had any other bone disease or anorexia nervosa (an eating disorder); or if you drink a lot of alcohol or smoke a great deal. Tell your doctor if you take any of the following medications: corticosteroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone); or medications for seizures such as carbamazepine (Tegretol), phenytoin (Dilantin), or phenobarbital (Luminal, Solfoton).
You should not use medroxyprogesterone injection for a long time (e.g., more than 2 years) unless no other method of birth control is right for you or no other medication will work to treat your condition. Your doctor may test your bones to be sure they are not becoming too thin before you continue to use medroxyprogesterone injection.
Keep all appointments with your doctor and the laboratory. Your doctor will monitor your health carefully to be sure you do not develop osteoporosis.
Talk to your doctor about the risks of using medroxyprogesterone injection.

Medroxyprogesterone is used to treat abnormal menstruation (periods) or irregular vaginal bleeding. Medroxyprogesterone is also used to bring on a normal menstrual cycle in women who menstruated normally in the past but have not menstruated for at least 6 months and who are not pregnant or undergoing menopause (change of life). Medroxyprogesterone is also used to prevent overgrowth of the lining of the uterus (womb) and may decrease the risk of cancer of the uterus in patients who are taking estrogen. Medroxyprogesterone is in a class of medications called progestins. It works by stopping the growth of the lining of the uterus and by causing the uterus to produce certain hormones.

Medroxyprogesterone comes as a tablet to take by mouth. It is usually taken once a day on certain days of a regular monthly cycle. To help you remember to take medroxyprogesterone, take it at around the same time every day on the days you are scheduled to take it. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take medroxyprogesterone exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Medroxyprogesterone may control your condition but will not cure it. Continue to take medroxyprogesterone according to your monthly schedule even if you feel well. Do not stop taking medroxyprogesterone without talking to your doctor.

Before using medroxyprogesterone injection,

tell your doctor and pharmacist if you are allergic to medroxyprogesterone (Depo-Provera, depo-subQ provera 104, Provera, in Prempro, in Premphase) or any other medications.

tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and aminoglutethimide (Cytadren). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

tell your doctor if you or anyone in your family has or has ever had breast cancer or diabetes. Also tell your doctor if you have or have ever had problems with your breasts such as lumps, bleeding from your nipples, an abnormal mammogram (breast x-ray), or fibrocystic breast disease (swollen, tender breasts and/or breast lumps that are not cancer); unexplained vaginal bleeding;irregular or very light menstrual periods; excessive weight gain or fluid retention before your period; blood clots in your legs, lungs, brain, or eyes; stroke or mini-stroke; migraine headaches; seizures; depression; high blood pressure; heart attack;  asthma; or heart, liver, or kidney disease.

tell your doctor if you think you might be pregnant, you are pregnant, or you plan to become pregnant. If you become pregnant while using medroxyprogesterone injection, call your doctor immediately. Medroxyprogesterone may harm the fetus.

tell your doctor if you are breast-feeding. You may use medroxyprogesterone injection while you are breast-feeding as long as your baby is 6 weeks old when you receive your first injection. Some medroxyprogesterone may be passed to your baby in your breast milk but this has not been shown to be harmful. Studies of babies who were breast-fed while their mothers were using medroxyprogesterone injection showed that the babies were not harmed by the medication.

if you are having surgery, including dental surgery, tell the doctor or dentist that you are using medroxyprogesterone injection.

you should know that your menstrual cycle will probably change while you are using medroxyprogesterone injection. At first, your periods will probably be irregular, and you may experience spotting between periods. If you continue to use this medication, your periods may stop completely. Your menstrual cycle will probably return to normal some time after you stop using this medication.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Medroxyprogesterone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:



changes in menstrual periods (See SPECIAL PRECAUTIONS)

weight gain

weakness

tiredness

nervousness

irritability

depression

difficulty falling asleep or staying asleep

hot flashes

breast pain, swelling, or tenderness

stomach cramps or bloating

leg cramps

back or joint pain

acne

loss of hair on scalp

swelling, redness, irritation, burning, or itching of the vagina

white vaginal discharge

changes in sexual desire

cold or flu symptoms

pain, irritation, lumps, redness or scarring in the place where the medication was injected

Some side effects can be serious. The following side effects are uncommon, but if you experience any of them, call your doctor immediately:



sudden shortness of breath

sudden sharp or crushing chest pain

coughing up blood

severe headache

nausea

vomiting

dizziness or faintness

change or loss of vision

double vision

bulging eyes

difficulty speaking

weakness or numbness in an arm or leg

seizure

yellowing of the skin or eyes

extreme tiredness

pain, swelling, warmth, redness, or tenderness in one leg only

menstrual bleeding that is heavier or lasts longer than normal

severe pain or tenderness just below the waist

rash

hives

itching

difficulty breathing or swallowing

swelling of the hands, feet, ankles, or lower legs

difficult, painful, or frequent urination

constant pain, pus, warmth, swelling, or bleeding in the place where the medication was injected
If you are younger than 35 years old and began to receive medroxyprogesterone injection in the last 4 to 5 years, you may have a slightly increased risk that you will develop breast cancer. Medroxyprogesterone injection may also increase the chance that you will develop a blood clot that moves to your lungs or brain. Talk to your doctor about the risks of using this medication.
Medroxyprogesterone injection is a long-acting birth control method. You might not become pregnant for some time after you receive your last injection. Talk to your doctor about the effects of using this medication if you plan to become pregnant in the near future.
Medroxyprogesterone injection may cause other side effects. Call your doctor if you have any unusual problems while receiving this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Your doctor will store the medication in his or her office.

Keep all appointments with your doctor.
Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking medroxyprogesterone.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
¶ This branded product is no longer on the market. Generic alternatives may be available.