Sorry, we do not offer this product as it requires refrigeration during shipping.
(den oh' sue mab)
Before receiving denosumab injection,
- tell your doctor and pharmacist if you are allergic to denosumab (Prolia, Xgeva), any other medications, latex, or any of the ingredients in denosumab injection. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
- you should know that denosumab injection is available under the brand names Prolia and Xgeva. You should not receive more than one product containing denosumab at a time. Be sure to tell your doctor if you are being treated with either of these medications.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: angiogenesis inhibitors such as bevacizumab (Avastin), everolimus (Afinitor, Zortress), pazopanib (Votrient), sorafenib (Nexavar), or sunitinib (Sutent); cancer chemotherapy medications; medications that suppress the immune system such as azathioprine (Azasan, Imuran), cyclosporine (Gengraf, Neoral, Sandimmune), methotrexate (Trexall), sirolimus (Rapamune), and tacrolimus (Astagraf XL, Prograf); or oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor if you have or have ever had a low level of calcium in your blood. Your doctor will probably check the level of calcium in your blood before you begin treatment and will probably tell you not to receive denosumab injection if the level is too low.
- tell your doctor if you have or have ever had anemia (condition in which the red blood cells do not bring enough oxygen to all the parts of the body); cancer; any type of infection, especially in your mouth; problems with your mouth, teeth, gums, or dentures; dental or oral surgery (teeth removed, dental implants); any condition that stops your blood from clotting normally; any condition that decreases functioning of your immune system; surgery on your thyroid gland or parathyroid gland (small gland in the neck); surgery to remove part of your small intestine; problems with your stomach or intestine that make it difficult for your body to absorb nutrients; or thyroid or kidney disease.
- tell your doctor if you are pregnant or plan to become pregnant, or if you plan to father a child. Denosumab injection may harm the fetus. You should not become pregnant while you are receiving denosumab injection and if receiving denosumab (Xgeva) for at least 5 months after your treatment. You should use a reliable method of birth control to prevent pregnancy while you are receiving denosumab injection and if receiving denosumab (Xgeva) for at least 5 months after your treatment. If you or your partner become pregnant while receiving denosumab injection, or within 5 months of your treatment with denosumab (Xgeva), call your doctor immediately.
- tell your doctor if you are breastfeeding. You should not breastfeed while you are receiving denosumab injection.
- you should know that denosumab injection may cause osteonecrosis of the jaw (ONJ, a serious condition of the jaw bone), especially if you have dental surgery or treatment while you are receiving this medication. A dentist should examine your teeth and perform any needed treatments, including cleaning or fixing ill-fitted dentures, before you start to receive denosumab injection. Be sure to brush your teeth and clean your mouth properly while you are receiving denosumab injection. Talk to your doctor before having any dental treatments while you are receiving this medication.
- red, dry, or itchy skin
- oozing or crusty blisters on skin
- peeling skin
- back pain
- pain in your arms
- muscle or joint pain
- runny nose
- sore throat
- muscle stiffness, twitching, cramps, or spasms
- numbness or tingling in your fingers, toes, or around your mouth
- difficulty breathing or swallowing
- swelling of the face, throat, tongue, or lips
- blurred vision
- fever or chills
- redness, tenderness, swelling or warmth of area of skin
- ear drainage or severe pain
- frequent or urgent need to urinate
- burning feeling when you urinate
- pain, numbness, swelling, or drainage from mouth, teeth, or jaw
- slow healing of the mouth or jaw
- severe abdominal pain
- ongoing pain that begins in the stomach area, but may spread to the back
- fast heart rate