Astagraf XL (Tacrolimus)
0.75mg Tablet (Extended-Release)
1mg Tablet (Extended-Release)
4mg Tablet (Extended-Release)
To comply with Canadian International Pharmacy Association regulations you are permitted to order a 3-month supply or the closest package size available based on your personal prescription. read more
(ta kroe' li mus)A small number of patients who used tacrolimus ointment or another similar medication developed skin cancer or lymphoma (cancer in a part of the immune system). There is not enough information available to tell whether tacrolimus ointment caused these patients to develop cancer. Studies of transplant patients and laboratory animals and an understanding of the way tacrolimus works suggest that there is a possibility that people who use tacrolimus ointment have a greater risk of developing cancer. More study is needed to understand this risk. Follow these directions carefully to decrease the possible risk that you will develop cancer during your treatment with tacrolimus ointment:
- Use tacrolimus ointment only when you have symptoms of eczema. Stop using tacrolimus ointment when your symptoms go away or when your doctor tells you that you should stop. Do not use tacrolimus ointment continuously for a long time.
- Call your doctor if you have used tacrolimus ointment for 6 weeks and your eczema symptoms have not improved, or if your symptoms get worse at any time during your treatment. A different medication may be needed.
- Call your doctor if your eczema symptoms come back after your treatment with tacrolimus ointment.
- Apply tacrolimus ointment only to skin that is affected by eczema. Use the smallest amount of ointment that is needed to control your symptoms.
- Do not use tacrolimus ointment to treat eczema in children who are younger than 2 years old. Do not use tacrolimus ointment 0.1% to treat eczema in children who are between 2 and 15 years old. Only tacrolimus ointment 0.03% may be used to treat children in this age group.
- Tell your doctor if you have or have ever had cancer, especially skin cancer, or any condition that affects your immune system. Ask your doctor if you are not sure if a condition that you have has affected your immune system. Tacrolimus may not be right for you.
- Protect your skin from real and artificial sunlight during your treatment with tacrolimus ointment. Do not use sun lamps or tanning beds, and do not undergo ultraviolet light therapy. Stay out of the sunlight as much as possible during your treatment, even when the medication is not on your skin. If you need to be outside in the sun, wear loose fitting clothing to protect the treated skin, and ask your doctor about other ways to protect your skin from the sun.
- Wash your hands with soap and water.
- Be sure that the skin in the affected area is dry.
- Apply a thin layer of tacrolimus ointment to all affected areas of your skin.
- Rub the ointment into your skin gently and completely.
- Wash your hands with soap and water to remove any leftover tacrolimus ointment. Do not wash your hands if you are treating them with tacrolimus.
- You may cover the treated areas with normal clothing, but do not use any bandages, dressings, or wraps.
- Be careful not to wash the ointment off of affected areas of your skin. Do not swim, shower, or bathe immediately after applying tacrolimus ointment.
Before using tacrolimus ointment,
- tell your doctor and pharmacist if you are allergic to tacrolimus ointment, injection, or capsules (Prograf), or any other medications.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention any of the following: antifungals such as fluconazole (Diflucan), itraconazole (Sporanox), and ketoconazole (Nizoral); calcium channel blockers such as diltiazem (Cardizem, Dilacor, Tiazac) and verapamil (Calan, Covera, Isoptin, Verelan); cimetidine (Tagamet); erythromycin (E.E.S., E-Mycin, Erythrocin); and other ointments, creams, or lotions. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor if you have a skin infection and if you have or have ever had kidney disease, Netherton's syndrome (an inherited condition that causes the skin to be red, itchy, and scaly), redness and peeling of most of your skin, any other skin disease, or any type of skin infection, especially chicken pox, shingles (a skin infection in people who have had chicken pox in the past), herpes (cold sores), or eczema herpeticum (viral infection that causes fluid filled blisters to form on the skin of people who have eczema). Also tell your doctor if your eczema rash has turned crusty or blistered or you think your eczema rash is infected.
- tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using tacrolimus ointment, call your doctor.
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are using tacrolimus ointment.
- ask your doctor about the safe use of alcoholic beverages while you are using tacrolimus ointment. Your skin or face may become flushed or red and feel hot if you drink alcohol during your treatment.
- avoid exposure to chicken pox, shingles, and other viruses. If you are exposed to one of these viruses while using tacrolimus ointment, call your doctor immediately.
- you should know that good skin care and moisturizers may help relieve the dry skin caused by eczema. Talk to your doctor about the moisturizers you should use, and always apply them after applying tacrolimus ointment.
- skin burning, stinging, redness or soreness
- tingling skin
- increased sensitivity of the skin to hot or cold temperatures
- swollen or infected hair follicles
- muscle or back pain
- flu-like symptoms
- stuffy or runny nose
- swollen glands
- crusting, oozing, blistering or other signs of skin infection
- cold sores
- chicken pox or other blisters
- swelling of the hands, arms, feet, ankles, or lower legs
The content on this page is for informational and educational purposes only and does not constitute professional medical advice. Patients should not use the information presented on this page for diagnosing a health-related issue or disease. Before taking any medication or supplements, patients should always consult a physician or qualified healthcare professional for medical advice or information about whether a drug is safe, appropriate or effective.