Before taking risedronate,
tell your doctor and pharmacist if you are allergic to risedronate, any other medications, or any of the ingredients in risedronate tablets or delayed-release tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients
tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: angiogenesis inhibitors such as bevacizumab (Avastin), everolimus (Afinitor, Zortress), pazopanib (Votrient), sorafenib (Nexavar), or sunitinib (Sutent); aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Ibu-Tab, Motrin, others) and naproxen (Aleve, Naprelan, Naprosyn, others); cancer chemotherapy; or oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos). If you are taking the delayed-release tablets, you should also tell your doctor if you are taking an H2 blocker such as cimetidine, famotidine (Pepcid), nizatidine (Axid), and ranitidine (Zantac) or a proton pump inhibitor such as esomeprazole (Nexium, in Vimovo), lansoprazole (Prevacid), omeprazole (Prilosec, Zegerid), pantoprazole (Protonix), and rabeprazole (AcipHex). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
you should know that Actonel and Atelvia both contain risedronate. You cannot take both of these medications at the same time.
if you are taking any other oral medications including vitamins, supplements, or antacids, take them at least 30 minutes after you take risedronate.
tell your doctor if you have or have ever had a low level of calcium in your blood or any problems with your esophagus and if you are unable to sit upright or stand upright for at least 30 minutes. Your doctor may tell you that you should not take risedronate.
tell your doctor if you are undergoing radiation therapy; if you have or have ever had difficulty swallowing; heartburn; ulcers or other problems with your stomach; anemia (condition in which the red blood cells do not bring enough oxygen to all the parts of the body); cancer; any type of infection, especially in your mouth; problems with your mouth, teeth, or gums; any condition that stops your blood from clotting normally; or dental or kidney disease.
tell your doctor if you are pregnant or are breastfeeding. Also tell your doctor if you plan to become pregnant at any time in the future, because risedronate may remain in your body for years after you stop taking it. Call your doctor if you become pregnant during or after your treatment with risedronate.
you should know that risedronate may cause severe bone, muscle, or joint pain. You may begin to feel this pain within days, months, or years after you first take risedronate. Although this type of pain may begin after you have taken risedronate for some time, it is important for you and your doctor to realize that it may be caused by risedronate. Call your doctor right away if you experience severe pain at any time during your treatment with risedronate. Your doctor may tell you to stop taking risedronate and your pain may go away after you stop taking the medication.
you should know that risedronate may cause osteonecrosis of the jaw (ONJ, a serious condition of the jaw bone), especially if you have dental surgery or treatment while you are taking the medication. A dentist should examine your teeth and perform any needed treatments, including cleaning or fixing ill-fitted dentures, before you start to take risedronate. Be sure to brush your teeth and clean your mouth properly while you are taking risedronate. Talk to your doctor before having any dental treatments while you are taking this medication.
talk to your doctor about other things you can do to prevent osteoporosis from developing or worsening. Your doctor will probably tell you to avoid smoking and drinking large amounts of alcohol and to follow a regular program of weight-bearing exercise.