Tasigna (Nilotinib Hydrochloride Monohydrate)
Prescription required. Can not be split. Product of Canada. Shipped from Canada.
Prescription required. May be split. Product of Turkey. Shipped from Mauritius.
This item is backorded. May require additional wait time.
To comply with Canadian International Pharmacy Association regulations you are permitted to order a 3-month supply or the closest package size available based on your personal prescription. read more
Nilotinib Hydrochloride Monohydrate Information
(nye loe' ti nib)Nilotinib may cause QT prolongation (an irregular heart rhythm that can lead to fainting, loss of consciousness, seizures, or sudden death). Tell your doctor if you or anyone in your family has or has ever had long QT syndrome (an inherited condition in which a person is more likely to have QT prolongation) or you have or have ever had low levels of potassium or magnesium in your blood, an irregular heartbeat, or liver disease. Tell your doctor and pharmacist if you are taking amiodarone (Cordarone, Pacerone); antifungals such as ketoconazole (Nizoral), itraconazole (Sporanox), or voriconazole (Vfend); chloroquine (Aralen); cisapride (Propulsid); clarithromycin (Biaxin, in Prevpac); disopyramide (Norpace); erythromycin (E.E.S., E-Mycin, Erythrocin); certain medications for human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) such as atazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), and saquinavir (Invirase); haloperidol; methadone (Dolophine, Methadose); moxifloxacin (Avelox); nefazodone; pimozide (Orap); procainamide (Procanbid, Pronestyl); quinidine; sotalol (Betapace, Betapace AF); telithromycin (Ketek); and thioridazine. If you experience any of the following symptoms, stop taking nilotinib and call your doctor immediately: fast, pounding, or irregular heartbeat; fainting; loss of consciousness; or seizures. Take nilotinib on an empty stomach, at least 1 hour before or 2 hours after eating any food. Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests, such as blood tests and electrocardiograms (EKGs, tests that record the electrical activity of the heart) before and during your treatment to be sure that it is safe for you to take nilotinib. Talk to your doctor about the risks of taking nilotinib.
Before taking nilotinib,
- tell your doctor and pharmacist if you are allergic to nilotinib or any other medications.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: certain angiotensin-receptor blockers such as irbesartan (Avapro) and losartan (Cozaar, in Hyzaar); anticoagulants (''blood thinners'') such as warfarin (Coumadin); aripiprazole (Abilify); certain benzodiazepines such as alprazolam (Xanax), diazepam (Valium), midazolam, and triazolam (Halcion); buspirone (Buspar); certain calcium channel blockers such as amlodipine (Norvasc), diltiazem (Cardizem, Dilacor, Tiazac, others), felodipine (Plendil), nicardipine (Cardene), nifedipine (Adalat, Procardia), nisoldipine (Sular), and verapamil (Calan, Isoptin, Verelan); certain cholesterol-lowering medications (statins) including atorvastatin (Lipitor), fluvastatin (Lescol), lovastatin (Mevacor),and simvastatin (Zocor); chlorpheniramine (Chlor-Trimeton, other cough and cold products); dexamethasone (Mymethasone); flecainide (Tambocor); certain medications for depression such as amitriptyline, desipramine (Norpramin), duloxetine (Cymbalta), imipramine (Tofranil), paroxetine (Paxil), and venlafaxine (Effexor); certain oral medications for diabetes such as glipizide (Glucotrol) and tolbutamide; certain medications that suppress the immune system such as cyclosporine (Neoral, Sandimmune) and tacrolimus (Prograf); certain medications for seizures such as carbamazepine (Equetro, Carbatrol, Tegretol), phenobarbital, and phenytoin (Dilantin, Phenytek); mexiletine; certain nonsteroidal anti-inflammatory drugs (NSAIDs) such as celecoxib (Celebrex), diclofenac (Voltaren), ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), and piroxicam (Feldene); ondansetron (Zofran); propafenone (Rythmol); quinine (Qualaquin); rifabutin (Mycobutin); rifampin (Rifadin); rifapentine (Priftin); risperidone (Risperdal); sildenafil (Viagra, Revatio); tamoxifen; testosterone (Androderm, Androgel, Striant, others); timolol; torsemide; tramadol (Ultram, in Ultracet); trazodone; and vincristine. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with nilotinib, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
- tell your doctor what herbal products you are taking, especially St. John's wort.
- tell your doctor if you have or have ever had any heart problems, pancreatitis (swelling of the pancreas, a gland behind the that produces substances to help with digestion), surgery to remove the entire stomach (total gastrectomy), or any condition that makes it difficult for you to digest lactose (milk sugar) or other sugars.
- tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while you are taking nilotinib. Talk to your doctor about birth control methods that you can use during your treatment. If you become pregnant while taking nilotinib, call your doctor immediately. Nilotinib may harm the fetus.
- tell your doctor if you are breast-feeding. You should not breast-feed while you are taking nilotinib.
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking nilotinib.
- loss of appetite
- difficulty falling asleep or staying asleep
- night sweats
- muscle cramps
- back, bone, joint, limb, or muscle pain
- hair loss
- dry or reddened skin
- numbness, burning, or tingling in the hands or feet
- unusual bleeding or bruising
- blood in urine
- bloody or black, tarry stools
- unusual tiredness or weakness
- fever, chills, sore throat, ongoing cough and congestion, or other signs of infection
- shortness of breath
- swelling of hands, ankles, feet, or face
- sudden stomach area pain
- yellowing of the skin and eyes