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Metronidazole



(me troe ni' da zole)

Flagyl®
Flagyl® 375
Flagyl® ER

Metronidazole can cause cancer in laboratory animals. Talk to your doctor about the risks and benefits of taking this medication.

Metronidazole injection is used to treat certain skin, blood, bone, joint, gynecologic, and abdominal (stomach area) infections caused by bacteria. It is also used to treat endocarditis (infection of the heart lining and valves), meningitis (infection of the membranes that surround the brain and spinal cord), and certain respiratory infections, including pneumonia. Metronidazole injection is also to prevent infection when used before, during, and after colorectal surgery. Metronidazole injection is in a class of medications called antibacterials. It works by killing bacteria and protozoa that cause infection.
Antibiotics such as metronidazole injection will not work for colds, flu, or other viral infections. Taking antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment.infections of the respiratory tract, including bronchitis, pneumonia

Metronidazole comes as a gel to be used in the vagina. Metronidazole is usually used as a single dose at bedtime (Nuvessa) or once daily for 5 consecutive days at bedtime (MetroGel Vaginal, Vandazole). Metronidazole is also used twice daily for 5 days (MetroGel Vaginal). Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use metronidazole exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.
Be careful not to get metronidazole gel in your eyes, mouth, or on your skin. If you do get it in your eyes, wash them with cool water and contact your doctor.
Do not have vaginal intercourse or use other vaginal products (such as tampons or douches) during your treatment with the vaginal gel.
Metronidazole gel for the vagina comes with a special applicator. Read the instructions provided with it and follow these steps:



Fill the special applicator that comes with the gel to the level indicated.

Lie on your back with your knees drawn upward and spread apart.

Gently insert the applicator into your vagina and push the plunger to release all of the medication.

Withdraw the applicator and dispose of it properly. If you are instructed to reuse the applicator, wash it with soap and warm water.

Wash your hands promptly to avoid spreading the infection.

Before using metronidazole injection,

tell your doctor and pharmacist if you are allergic to metronidazole, any other medications, or any of the ingredients in metronidazole injection. Ask your pharmacist for a list of the ingredients.

tell your doctor if you are have taken or are taking disulfiram (Antabuse). Your doctor will probably tell you not to use metronidazole injection if you are taking this medication or have taken it within the last 2 weeks.

tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven), busulfan (Buselfex, Myleran), cimetidine (Tagamet), corticosteroids, lithium (Lithobid), phenobarbital, and phenytoin (Dilantin, Phenytek). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with metronidazole injection, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

tell your doctor if you have or have ever had Crohn's disease (a condition in which the body attacks the lining of the digestive tract, causing pain, diarrhea, weight loss, and fever), a yeast infection, edema (fluid retention and swelling; excess fluid held in body tissues), or blood, kidney, or liver disease.

remember not to drink alcoholic beverages or take products with alcohol or propylene glycol while receiving metronidazole injection and for at least 3 days after treatment is finished. Alcohol and propylene glycol may cause nausea, vomiting, stomach cramps, headache, sweating, and flushing (redness of the face) when taken during treatment with metronidazole injection.

tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using metronidazole injection, call your doctor.

Unless your doctor tells you otherwise, continue your normal diet.

Apply the cream, lotion, or gel as soon as you remember, but do not apply a double dose to make up for a missed dose.

Metronidazole may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:



increased skin redness, dryness, burning, irritation, or stinging

teary eyes

pink eye

nausea

Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:



numbness, pain, burning, or tingling in your hands or feet

rash

itching

hives
Metronidazole may cause other side effects. Call your doctor if you have any unusual problems while using this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light, excess heat and moisture (not in the bathroom).
It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them.  However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community.  See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

Before having any laboratory test, tell your doctor and the laboratory personnel that you are receiving metronidazole injection.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.