Xeljanz (Tofacitinib Citrate )

They need to know if you have any of these conditions: -cancer -diabetes -high cholesterol -HIV or AIDS -immune system problems -infection (especially a virus infection such as hepatitis B, chickenpox, cold sores, or herpes) -kidney disease -liver disease -low blood counts, like low white cell, platelet, or red cell counts -lung or breathing disease, like asthma -organ transplant -stomach or intestine problems -tuberculosis, a positive skin test for tuberculosis, or have recently been in close contact with someone who has tuberculosis -an unusual or allergic reaction to tofacitinib, other medicines, foods, dyes, or preservatives -pregnant or trying to get pregnant -breast-feeding

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. You can take it with or without food. If it upsets your stomach, take it with food. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice. A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time. Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. NOTE: This medicine is only for you. Do not share this medicine with others.

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Do not take this medicine with any of the following medications: -baricitinib This medicine may also interact with the following medications: -antiviral medicines for hepatitis, HIV or AIDS -azathioprine, cyclosporine, or other immunosuppressive drugs -biologic medicines such as abatacept, adalimumab, anakinra, certolizumab, etanercept, golimumab, infliximab, rituximab, secukinumab, tocilizumab, ustekinumab -certain medicines for fungal infections like fluconazole, itraconazole, ketoconazole, voriconazole -certain medicines for seizures like carbamazepine, phenobarbital, phenytoin -live vaccines -rifampin -supplements, such as St. John's wort

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse. Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your doctor. These medicines may hide a fever. Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.

Side effects that you should report to your doctor or health care professional as soon as possible: -allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue -breathing problems -dizziness -signs of infection - fever or chills, cough, sore throat, pain or trouble passing urine -signs and symptoms of liver injury like dark yellow or brown urine; general ill feeling or flu-like symptoms; light-colored stools; loss of appetite; nausea; right upper belly pain; unusually weak or tired; yellowing of the eyes or skin -stomach pain or a sudden change in bowel habits -unusually weak or tired Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome): -diarrhea -headache -muscle aches -runny nose -sinus trouble

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Keep out of the reach of children. Store between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medicine after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.